| CAS No.: | 53123-88-9 |
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| Formula: | C51h79no13 |
| EINECS: | 610-965-5 |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Pharma Grade |
| Samples: |
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| Customization: |
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Rapamycin, also known as sirolimus, is a naturally occurring compound initially discovered in the soil of Easter Island, known as Rapa Nui. It is produced by a bacterium called Streptomyces hygroscopicus. Rapamycin belongs to a class of drugs called macrolide immunosuppressants.
Rapamycin was originally developed as an immunosuppressant drug to prevent organ transplant rejection and treat certain autoimmune diseases. It works by inhibiting the activity of a protein called mammalian target of rapamycin (mTOR), which plays a crucial role in cell growth, proliferation, and immune response.
In addition to its immunosuppressive properties, rapamycin has been found to have various other effects and potential medical applications. Some of these include:
Anti-cancer properties: Rapamycin has shown promise as a potential anti-cancer agent. It can inhibit the growth of tumor cells by blocking mTOR signaling pathways involved in cell division and angiogenesis (the formation of new blood vessels that supply nutrients to tumors).
Anti-aging properties: Rapamycin has gained attention for its potential to extend lifespan and improve healthspan in various organisms, including yeast, worms, flies, and mice. It is believed to act on cellular and molecular pathways associated with aging and age-related diseases.
Treatment of certain rare genetic disorders: Rapamycin has been used to manage certain rare genetic disorders like tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM). These conditions involve the abnormal growth of noncancerous tumors, and rapamycin can help inhibit their progression.
Cardiac applications: Rapamycin-eluting stents are commonly used in interventional cardiology to prevent blockage of arteries after angioplasty. The drug coating on the stent helps inhibit the growth of scar tissue that can lead to restenosis.
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Product Name
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Rapamycin |
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Category
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Plant Extracts
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Analysis
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HPLC
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Storage
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Keep in cool and dry place, well-closed, away from moisture or direct sunlight.
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Function:
Rapamycin has multiple functions and can affect various biological processes in the body. Here are some of the key functions of rapamycin:
Immunosuppression: Rapamycin is primarily used as an immunosuppressant drug to prevent organ transplant rejection and treat certain autoimmune diseases. It suppresses the immune system by inhibiting the activation and proliferation of T-lymphocytes, a type of white blood cell involved in immune responses.
Inhibition of mTOR signaling: Rapamycin specifically targets a protein called mammalian target of rapamycin (mTOR) and inhibits its activity. mTOR is a central regulator of cell growth, division, and metabolism. By inhibiting mTOR, rapamycin can interfere with cell signaling pathways involved in these processes.
Anti-cancer effects: Rapamycin has demonstrated anti-cancer properties by inhibiting tumor growth and metastasis. By blocking mTOR signaling, it disrupts the cellular mechanisms that promote cancer cell proliferation, survival, and angiogenesis. Rapamycin and its analogs (such as everolimus and temsirolimus) have been approved for the treatment of certain cancers, including renal cell carcinoma and certain types of advanced breast cancer.
Anti-inflammatory properties: Rapamycin has shown anti-inflammatory effects in various disease models. It can reduce inflammation by modulating immune responses and inhibiting the production of pro-inflammatory molecules.
Modulation of autophagy: Autophagy is a cellular process involved in the degradation and recycling of damaged or unnecessary cellular components. Rapamycin can induce autophagy by inhibiting mTOR, leading to the enhanced removal of dysfunctional cellular components and potentially promoting cellular health and longevity.
Anti-fibrotic effects: Rapamycin has been investigated for its potential to inhibit the development of fibrosis, a condition characterized by excessive scarring and tissue remodeling. It can interfere with the signaling pathways involved in fibrotic processes and reduce the deposition of extracellular matrix proteins.
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