| Customization: | Available |
|---|---|
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
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| Product Name: | Miriplatin |
| Synonyms: | [(1R,2R)-1,2-Cyclohexanediamine]bis(myristato)platinum;Miripla;SM 11355;(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kappaN,kappaN'])bis(myristato-kappaO)platinum;(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kappaN,kappaN'])bis(myristato-kappaO)platinum(II);(SP-4-2)-[(1R,2R)-1,2-Cyclohexanediamine-kappaN,kappaN'])bis... |
| CAS: | 141977-79-9 |
| MF: | C34H66N2O4Pt |
| MW: | 762 |
Meplatin is effective in the treatment of liver cancer, malignant lymphoma, non-small cell lung cancer, small cell lung cancer and superficial bladder cancer. Its mechanism of action is similar to that of other platinum drugs. It acts on DNA by producing alkylated conjugates to form intra- and inter-strand cross-links, thereby inhibiting DNA synthesis and replication and inhibiting tumor growth. Animal studies have shown that after TACE, Miplatin suspension can target and accumulate in tumor tissue and release active ingredients slowly, exerting a good anti-tumor effect, and its anti-cancer activity is better than that of netstatin. The clinical study showed that the TEV ratios of the Miplatin group and the net statin group were 26.5% (22/83) and 17.9% (7/39), respectively; the 2-year survival rates of the two groups were 75.9 and 70.3%, respectively; The 3-year survival rates of Chemicalbook were 58.4% and 48.7%, respectively, and the efficacy of the two drugs was similar. Compared with net statin, the miplatin group had no hepatic vascular injury (does not affect re-treatment), and reduced irreversible damage to the hepatobiliary system (which had an adverse effect on prognosis), and the safety was better than net statin. ester. Miplatin is an anticancer drug that is dissolved in special iodized poppy seed oil fatty acid ethyl ester and administered in the hepatic artery. At the tumor site, the platinum component in the suspension can be slowly released into the blood or tissue for a long time. The platinum bivalent compound binds to DNA, inhibits the proliferation of cancer cells by preventing DNA synthesis, and improves the anti-cancer effect. Clinical trials have shown that this product has shown good anti-cancer effects in patients with hepatocellular carcinoma for the first time, or in some patients who have undergone other treatments such as liver resection.
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