Xazb Supply Chenodeoxycholic Acid/ Cdca Powder 80%, 90%, 95%, 98% CAS 474-25-9

• Customization: Available
• Transport Package: Foil Bag
• Specification: 99%
• Trademark: XAZB
• Origin: China

Product Description

XAZB Supply Chenodeoxycholic Acid/ Udca Powder 80%, 90%, 95%, 98% CAS 474-25-9

 

 

Item	Specifications	Results
Appearance	White or yellowish crystalline powder	Conforms
Assay	>98.0%	99.3%
Molecular weight	392.6	Conforms
Melting point	165-167ºC	166ºC
Ratio of rotation	+11°-+13°	+11°
Acidity	Less 0.5ml	0.23ml
Chloride	Less 0.016%	Conforms
Barium salt	conforms	Conforms
Loss on drying	Less 2.0%	1.0%
Residue on ignition	Less 0.2%	0.14%

Chenodeoxycholic acid is a bile acid. Bile acids are steroid acids found predominantly in the bile of mammals. The distinction between different bile acids is minute, depending only on the presence or absence of hydroxyl groups on positions 3, 7, and 12. Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Bile acids are also steroidal amphipathic molecules derived from the catabolism of cholesterol. They modulate bile flow and lipid secretion, are essential for the absorption of dietary fats and vitamins, and have been implicated in the regulation of all the key enzymes involved in cholesterol homeostasis. Bile acids recirculate through the liver, bile ducts, small intestine and portal vein to form an enterohepatic circuit. They exist as anions at physiological pH and, consequently, require a carrier for transport across the membranes of the enterohepatic tissues. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids have potent toxic properties (e.g. membrane disruption) and there are a plethora of mechanisms to limit their accumulation in blood and tissues.Usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.

 

 

Chenodiol suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid in an expanded bile acid pool. These actions contribute to biliary cholesterol desaturation and gradual dissolution of radiolucent cholesterol gallstones in the presence of a gall-bladder visualized by oral cholecystography. Bile acids may also bind the the bile acid receptor (FXR) which regulates the synthesis and transport of bile acids.

Chenodeoxycholic acid is a naturally occurring bile acid that is used to treat patients with genetic deficiencies in the synthesis of bile acids. When given in high doses, cholic acid replacement therapy has been linked to minor elevations in serum aminotransferase levels, but it has not been linked to instances of clinically apparent acute liver injury with jaundice.

 

Chenodiol suppresses hepatic synthesis of both cholesterol and cholic acid, gradually replacing the latter and its metabolite, deoxycholic acid in an expanded bile acid pool.