Factory Supply Bulk Nystatine Nistatina 99% Nystatin

• CAS No.: 1400-61-9
• Formula: C47h75no17
• EINECS: 215-749-0
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Refined
• Model NO.: 1400-61-9
• Colour: White
• MOQ: 1kg
• Sample: Yes
• Certificate: ISO, FDA
• Transport Package: 25kgs/Drum
• Specification: 99%
• Trademark: ZB
• Origin: China
• Production Capacity: 100000kgs/Month

Product Description

                                                            Nystatin
 

Nystatin is a polyene antifungal drug to which many molds and yeast infections are sensitive, including Candida.Cutaneous, vaginal, mucosal and esophageal Candida infections usually respond well to treatment with nystatin.Like a-mphotericin B and natamycin, nystatin binds to ergosterol, a major component of the fungal cell membrane. When present in sufficient concentrations, it forms pores in the membrane that lead to K+ leakage and death of the fungus.

Product Name	Nystatin
CAS	1400-61-9
Appearance	Yellow powder
MF	C47H75NO17
Molecular Weight	926.095
Purity	99%
Storage	Keep in a cool, dry, dark location in a tightly sealed container or cylinder
Shelf Life	24 Months

Test items		Standard	Result
Description		Light yellow powder	Conforms
Identification	IR	IR spectrum of sample is the same as working standard	Conforms
	HPLC	HPLC RT of the sample is the same as the working standard	Conforms
Melting point		165.0°C~169.0°C	Conforms
Optical rotation		-23°~-29°	-27.4°
Loss on drying		NMT 1.0 %	0.17%
Residue on ignition		NMT 0.1 %	0.03%
Heavy metals		NMT 20ppm	Conforms
Related substances
Impurity A		NMT 0.1 %	Not detected
Impurity B		NMT 0.1 %	Not detected
Impurity C		NMT 0.1 %	0.02%
Single impurity		NMT 0.2 %	0.17%
Total impurity		NMT 1.0 %	0.60%
Assay		NLT 99.0%	99.0%

APPLICATION
1. Nystatin is often used as prophylaxis in patients who are at risk for fungal infections, such as AIDS patients with a low CD4+ count and patients receiving chemotherapy.
2. It is prescribed in units, with doses varying from 100,000 (for oral infections) to 1 million (for intestinal ones). As it is not absorbed from the gut, it is safe for oral use and does not have problems of drug interactions.
3. It is also used in cellular biology as an inhibitor of the lipid raft-caveolae endocytosis pathway on mammalian cells, at concentrations around 3 µg/mL.
4. In certain cases, nystatin has been used to prevent the spread of mold on objects such as works of art. For example, it was applied to wood panel paintings damaged as a result of the Arno River Flood of 1966 in Florence, Italy.